In this talk I will discuss the main aspects of the cosmological constant problem and present a mechanism that sequesters vacuum energy generated by matter fields from gravity. I will emphasise the global nature of the problem and present a theory that only affects the trace of the gravitational field equations in the extreme infra-red. I will argue that the sequestering is effective regardless of the order of the loop expansion to which the vacuum energy is calculated thereby eliminating the need to repeatedly fine tune a classical counter term.